In recent years, with the development of medical genetics, the study found that many symptoms are related to heredity, such as colorectal cancer (CRC), is divided into hereditary colorectal cancer and sporadic colorectal cancer. It is reported that about 80-85% of CRC is caused by chromosomal instability (CIN), including familial adenomatous polyposis (FAP) and sporadic CRC (APC, P53, DCC, KRAS and other mutations); -20% of the CRC is mainly caused by microsatellite instability (MSI), including hereditary nonpolyposis colorectal cancer (HNPCC, also known as Lynch syndrome) and sporadic MSI (+) CRC.
Lynch syndrome, is the MMR gene germline mutations caused by the dominant genetic disease. More than 90% of Lynch syndrome with MSI characteristics, and sporadic colorectal cancer in about 15%, so the clinical use of MSI can be used to detect Lynch syndrome screening. NCCN experts strongly recommend MSI testing in all colon cancer patients younger than 50 years of age because it is more likely to be Lynch's syndrome.
Genomics has been committed to the field of genetic testing product development and production, the first domestic tumor cell microsatellite instability (MSI) detection kit, accurate and comprehensive testing, including NCI recommendations of all single nucleotide sites, and increased availability To identify the detection of potential sample contamination or contamination of the subject, reducing the risk of error (Patent No .: ZL 2011 1 0152226. X)